Drug resistant tuberculosis (TB) in China makes up about
The authors explained that they obtained their data from local and regional surveys in
Yanlin Zhao, Ph.D., Shaofa Xu, M.D., Lixia Wang, M.S., and team estimated what proportion of Chinese TB cases were drug resistant by cluster-randomized sampling of cases in the national public health system, and resistance testing for the first-line use of the following antibiotics, streptomycin, ethambutol, rifampin, and isoniazid, as well as the second-line medications kanamycin and ofloxacin.
They also used patient-interview data in compiling their estimate.
Below are some highlighted data from their study:
· Out of 3,037 new TB cases, 5.7% had MDR (multidrug-resistant) TB
· Out of 892 previously treated cases, 25.6% had MDR TB. MDR means the TB is resistant to at least rifampin and ironiazid
· Out of all patients with TB, new and old cases,
· Out of all patients with TB,
· About 8% of all MDR TB patients had "extensively drug-resistant TB". Extensively drug-resistant TB refers to infection that is resistant to at least isoniazid, kanamycin, rifampin, and ofloxacin
· There were 110,000 MDR TB incidence cases in 2007
· There were 8,200 extensively drug-resistance TB cases in 2007
· In the majority of cases, extensively drug-resistance TB and MDR TB resulted from primary transmission
· Those with the highest risk of MDR TB were patients who had received their last treatment in a TB hospital
· 43.8% of the 226 patients with MDR B had not completed their last treatment. The majority of them had received treatment in hospital. Even among those who completed their treatment, TB recurred after being treated in the public health system.
In an Abstract in the same journal, the authors wrote:
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Article reference:National Survey of Drug-Resistant Tuberculosis in China"
Yanlin Zhao, Ph.D., Shaofa Xu, M.D., Lixia Wang, M.S., Daniel P. Chin, M.D., Shengfen Wang, Ph.D., Guanglu Jiang, B.S., Hui Xia, M.S., Yang Zhou, M.S., Qiang Li, M.S., Xichao Ou, M.S., Yu Pang, Ph.D., Yuanyuan Song, B.S., Bing Zhao, B.S., Hongtao Zhang, Ph.D., Guangxue He, B.S., Jing Guo, Ph.D., and Yu Wang, M.D.
N Engl J Med 2012; 366:2161-2170June 7, 2012